Association study between schizophrenia and the DISC1 gene polymorphism

نویسندگان

  • Ali Mohammad Foroughmand Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran
  • Atefeh Pooryasin Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
  • Hamid Galehdari Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz-Iran
  • Maryam Haidari Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
  • Nahid Khajeh-Mogehi Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
  • Seyed Reza Kazeminejad Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
  • Shiva Hosseini Dept of genetics, College of Sciences, Shahid Chamran University, Ahvaz, Iran
چکیده مقاله:

  Abstract   Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome   position 1q42, was initially identified at the breakpoint of a balanced translocation,   t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large   Scottish family.   Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia   on the basis of DSM-IV criteria and 200 normal controls, which were gathered   from Iran. The allele and genotype frequencies of the polymorphism were determined   using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism   (PCR-RFLP) and the data were analyzed by Logistic Regression test.   Results: In this study we genotyped the rs821616 polymorphism (Serin704Cystein)   located within exon 11 of the DISC1 gene. The samples were matched on the basis   of sex and ethnicity. We used the case control study to determine the possible association between the ser704cys (rs821616) polymorphism and Schizophrenia. Analysis of data in the samples, revealed no association between the rs821616 polymorphism and Schizophrenia (OR= 0.697, 95% CI= 0.47-1.033, P=0.072).   Conclusion: In this study we did not find any association between the rs821616   SNPand schizophrenia.  

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

association study between schizophrenia and the disc1 gene polymorphism

abstract   background: the disrupted-in-schizophrenia 1 (disc1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large scottish family.   methods: our samples included 200 unrelated patients diagnosed with schizophrenia on the basis of dsm-iv criteria and 200 norm...

متن کامل

Study of the association between DRD2 Gene Ser311Cys and GSTM1 Gene polymorphism in Schizophrenia

Introduction: Schizophrenia is a mental disorder affecting 1% of the world's population. Two of genes have been recognized to be involved in development of this disease: DRD2 and GSTM1. Methods: This case-control study included 100 patients suffering from schizophrenia who referred to Yazd Neuropsychiatry Hospital. Also, 100 healthy patients without schizophrenia were selected as the control g...

متن کامل

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese

BACKGROUND Previous studies report that various single nucleotide polymorphisms (SNP) in the Disrupted-in Schizophrenia 1 (DISC1) gene are closely associated with schizophrenia, but there are no studies that assess the relationship of age of onset of schizophrenia with these SNPs. OBJECTIVE Investigate the relationship between the rs821633 SNP in the DISC1 gene and the occurrence and age of o...

متن کامل

Association the study of between CGA rs6631A>T gene polymorphism with the risk of male infertility

 Introduction: The CGA gene encodes alpha subunit of glycoprotein hormones that are involved in the fertility process. The aim of this study was to evaluate the relationship between glycoprotein hormones, alpha polypeptide (CGA)  rs6631A> T gene polymorphism with the risk of men with azoospermia or severe oligozoospermia. Methods:  This study was conducted in a case-control study on 200 bloo...

متن کامل

Association between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion

Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 24  شماره 1

صفحات  29- 34

تاریخ انتشار 2010-05

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023